Contact Information
607 S. Matthews Ave.
M/C 148
Urbana, IL 61801
Office Hours
Research Interests
Evolution of primate immunity, human immune variation, sepsis, severe infections, plague, pneumonia, Toxoplasma, SAR-CoV-2/COVID-19, host-pathogen interactions, immunogenomics, evolutionary medicine, the immunology of labour and economics.
Research Description
I ask why do some people get severe infections? More specifically, why do some people get sick when others do not? My lab examines how both the human experience and our evolutionary past affect immune system function, health and disease. With a specific focus on severe infections and sepsis, we examine the functional divergence and diversification of primate immune systems, how past pandemics affect present day immune function diversity and how life experience and especially how the job you work affects the innate immune responses.
Our lab team also develops protocol to decrease our environmental footprint and plastic waste, and increase the resiliency of land on which we work.
Education
2012, PhD, City University of New York Graduate Center, Anthropology
Grants
Champaign-Urbana Public Health District, Block grant - Project: Pop-up COVID-19 testing and Flu vaccination in vulnerable neighbourhoods in ChampaignCounty. (Co-PI) (2020)
National Science Foundation #BCS- 1750675. Human population history and the evolution of human immune function (PI) (2018-present)
UIUC Center for Social and Behavioral Sciences - Project: Identifying SARS-COV-2 critical control points in agricultural communities (Co-PI) (2020-present)
UIUC Student Sustainability Committee - Project: Joint Pollinator Garden and Composting Systems to Offset Environmental Impact and Reinforce Responsible Stewardship in Research (PI) (2019-present)
UIUC Student Sustainability Committee - Davenport Hall Carbon Garden (CoPI) (2018-2020)
Awards and Honors
2021 UIUC LAS Impact Award – Jessica Brinkworth “For leading efforts to provide underrepresented groups in the Rantoul and Champaign-Urbana communities with COVID-19 testing, flu vaccinations during the pandemic.”
2021 UIUC LAS Impact Award – Labour, Health. Equity, Action Project (LHEAP). “For providing vitally important COVID-19 testing to an underserved Illinois community”. Jessica Brinkworth, Korinta Maldonado, Ellen Moodie, Gilberto Rosas, & Rachel Whitaker
2020 Teacher Ranked as Excellent – University of Illinois Urbana-Champaign
2019 Gabriel W. Lasker Award for most significant contribution to the journal Human Biology in the year 2018
2018 Teacher Ranked as Excellent – University of Illinois Urbana-Champaign
Courses Taught
ANTH 407 - Evolutionary Immunology
ANTH 199 - On Race and Health (soon to be Race, your Cells and Health) FALL 2021!!
ANTH 249 - Evolution of Health and Disease
ANTH 240 - Introduction to Biological Anthropology
Additional Campus Affiliations
Carl R. Woese Institute for Genomic Biology (Infection Genomics for One Health, and Gene Networks in Neural and Developmental Plasticity themes)
Department of Evolution, Ecology and Behavior
Center for Social and Behavioral Sciences
External Links
Recent Publications
Brinkworth, J. F., & Valizadegan, N. (2021). Sepsis and the evolution of human increased sensitivity to lipopolysaccharide. Evolutionary anthropology, 30(2), 141-157. https://doi.org/10.1002/evan.21887
Hawash, M. B. F., Sanz-Remón, J., Grenier, J. C., Kohn, J., Yotova, V., Johnson, Z., Lanford, R. E., Brinkworth, J. F., & Barreiro, L. B. (2021). Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity. Proceedings of the National Academy of Sciences of the United States of America, 118(13), [2015855118]. https://doi.org/10.1073/PNAS.2015855118
Brinkworth, J. F., & Alvarado, A. S. (2020). Cell-Autonomous Immunity and The Pathogen-Mediated Evolution of Humans: Or How Our Prokaryotic and Single-Celled Origins Affect The Human Evolutionary Story. Quarterly Review of Biology, 95(3), 215-246. https://doi.org/10.1086/710389
Brinkworth, J. F., & Babbitt, C. C. (2018). Immune system promiscuity in human and nonhuman primate evolution. Human biology, 90(4), 251-269. https://doi.org/10.13110/humanbiology.90.4.01
Gassen, J., Prokosch, M. L., Makhanova, A., Eimerbrink, M. J., White, J. D., Proffitt Leyva, R. P., Peterman, J. L., Nicolas, S. C., Reynolds, T. A., Maner, J. K., McNulty, J. K., Eckel, L. A., Nikonova, L., Brinkworth, J. F., Phillips, M. D., Mitchell, J. B., Boehm, G. W., & Hill, S. E. (2018). Behavioral immune system activity predicts downregulation of chronic basal inflammation. PloS one, 13(9), [e0203961]. https://doi.org/10.1371/journal.pone.0203961
